RA-and other Connective Tissue diseases-Helped by Gluten Free-J Amer Medical Assoc

Posted by:  Kevin G. Parker, D.C.

Written by:  ARTICLE | March 7, 1966-Journal of American Medical Association- JAMA

comment from me….Yes, that says 1966 folks!

Gluten and the Small Intestine in Rheumatoid Arthritis

Henry J. Binder, MD; William M. O’Brien, MD; Howard M. Spiro, MD; J. William Hollingsworth, MD
JAMA. 1966;195(10):857-858. doi:10.1001/jama.1966.03100100109033.

An entirely new concept of the pathogenesis of rheumatoid arthritis and other connective-tissue diseases, a theory in which a genetically determined abnormality of the small intestine is the basic defect, has been proposed.

Shatin’s hypothesis1 is that patients with rheumatoid arthritis are heterozygous for nontropical sprue (adult celiac disease).

Although they have no intestinal complaints, the intestinal mucosa is abnormal and important metabolites essential to connective tissue are not absorbed.

The clinical expression of this heterozygotic condition is rheumatoid arthritis. He further states that the worldwide distribution of rheumatoid arthritis corresponds to the distribution of wheat ingestion, lending indirect support for his hypothesis.

The validity of this theory is strengthened by Shatin’s report that 18 out of 18 patients with rheumatoid arthritis improved on a gluten-free diet, often within two weeks after the beginning of the dietary restriction of cereal grains.

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