Dementia and Glucose Levels-N Engl J Med 2013

Posted by:  Kevin G. Parker, D.C.

N Engl J Med 2013; 369:540-548August 8, 2013DOI: 10.1056/NEJMoa1215740

Glucose Levels and Risk of Dementia

Paul K. Crane, M.D., M.P.H., Rod Walker, M.S., Rebecca A. Hubbard, Ph.D., Ge Li, M.D., Ph.D., David M. Nathan, M.D., Hui Zheng, Ph.D., Sebastien Haneuse, Ph.D., Suzanne Craft, Ph.D., Thomas J. Montine, M.D., Ph.D., Steven E. Kahn, M.B., Ch.B., Wayne McCormick, M.D., M.P.H., Susan M. McCurry, Ph.D., James D. Bowen, M.D., and Eric B. Larson, M.D., M.P.H.

CONCLUSIONS:  Our results suggest that higher glucose levels may be a risk factor for dementia, even among persons without diabetes. (Funded by the National Institutes of Health.)

BACKGROUND
Diabetes is a risk factor for dementia. It is unknown whether higher glucose levels increase the risk of dementia in people without diabetes.
METHODS
We used 35,264 clinical measurements of glucose levels and 10,208 measurements of glycated hemoglobin levels from 2067 participants without dementia to examine the relationship between glucose levels and the risk of dementia. Participants were from the Adult Changes in Thought study and included 839 men and 1228 women whose mean age at baseline was 76 years; 232 participants had diabetes, and 1835 did not. We fit Cox regression models, stratified according to diabetes status and adjusted for age, sex, study cohort, educational level, level of exercise, blood pressure, and status with respect to coronary and cerebrovascular diseases, atrial fibrillation, smoking, and treatment for hypertension.
RESULTS
During a median follow-up of 6.8 years, dementia developed in 524 participants (74 with diabetes and 450 without). Among participants without diabetes, higher average glucose levels within the preceding 5 years were related to an increased risk of dementia (P=0.01); with a glucose level of 115 mg per deciliter (6.4 mmol per liter) as compared with 100 mg per deciliter (5.5 mmol per liter), the adjusted hazard ratio for dementia was 1.18 (95% confidence interval [CI], 1.04 to 1.33). Among participants with diabetes, higher average glucose levels were also related to an increased risk of dementia (P=0.002); with a glucose level of 190 mg per deciliter (10.5 mmol per liter) as compared with 160 mg per deciliter (8.9 mmol per liter), the adjusted hazard ratio was 1.40 (95% CI, 1.12 to 1.76).

Related articles:
Dementia and How Saturated Fat is Good for You- Emily Deans, M.D.

Vitamin D3 Helps Clear Amyloid in Alzheimer’s Disease

Blood Sugar Control Improved by Weight Training

Fish oil and Dementia-British Medical Journal

Omega 3’s- Key thoughts

Diabetes Type 2-Weight Training Reduces Risk-Arch Intern Med. 2012

Diabetics Diet-Paleolithic diet is better-Cardiovasc Diabetol. 2009

Aerobic or Anaerobic Training Best For Getting Rid of Belly Fat

Diabetes Shrinks Elderly Brain-ScienceDaily 2012

Diabetes Type 2 Reversal with diet-Diabetologia 2011

Exercise and Chiropractic-Part of the Anti-aging Puzzle

Exercise and the brain: something to chew on-Henriette van Praag-Trends in Neurosciences Vol.32 No.5

If you are suffering from: Sports Injuries, Sprains, Strains, Car accident,  Herniated Disc, Disc Bulge, Degenerative Disc Disease, Neck pain, Headaches, Low back pain, of just want to feel better and have better life performance– please call our office in Irvine, California- at 949.857.1888or visit our website at ADJUST2IT to learn more about Functional Fitness Chiropractic, Sports massage, Myofascial Release, Corrective Exercise, Non Surgical Spinal Decompression, Class IV laser, Functional Endocrinology and Functional Nutrition.