DHA-Fish oil-Resolves Inflammation-FASExperimental Biology-2013

Posted by:  Kevin G. Parker, D.C.

Written by:  ScienceDaily.com

Journal Article:  Federation of American Societies for Experimental Biology

Key points not in the article: 

1.Your prime objective for consuming Omega 3 should be to get DHA (Docosahexaenoic Acid) into your body.More related articles in comments section.

2. Flaxseed contains alpha linolenic acid, which your body has to convert to DHA and EPA.

3. For the elderly this conversion process does NOT work very well.

4. The best source of DHA is from fish oil. However, there are some drawbacks with many fish oils:

5. Use fish oils which have been molecularly distilled, or are from impeccable sources with a reliable certificate of analysis.

Chronic inflammation is a major factor in problems from arthritis to cardiovascular disease, and DHA is known to help.

New research in The FASEB Journal, explains why DHA is important in reducing inflammation, and provides an important lead to finding new drugs that will help bring people back to optimal health.

Researchers found that macrophages use DHA to produce “maresins,” which are the “switch” that turns inflammation off and switches on resolution.

Chronic inflammation is a major factor in a wide range of problems from arthritis to cardiovascular disease, and DHA (found in fish oil) is known to temper this problem.

A new research report appearing in the July 2013 issue of The FASEB Journal, helps explain why DHA is important in reducing inflammation, and provides an important lead to finding new drugs that will help bring people back to optimal health.

Specifically, researchers found that macrophages (a type of white blood cell) use DHA to produce “maresins,” which serve as the “switch” that turns inflammation off and switches on resolution.

“We hope that the results from this study will enable investigators to test the relevance of the maresin pathway in human disease,” said Charles N. Serhan, Ph.D., a researcher involved in the work from the Brigham & Women’s Hospital and Harvard Medical School in Boston, Mass.

“Moreover, we hope to better understand resolution biology and its potential pharmacology so that we can enhance our ability to control unwanted inflammation and improve the quality of life.”

To make this discovery, Serhan and colleagues deconstructed the biosynthetic pathway for maresin biosynthesis and found that human macrophages are responsible for converting DHA to the novel epoxide intermediate “13S, 14S-epoxy-maresin.”

Then, they learned how to synthesize the molecule and found that maresins caused macrophages to change their “type” so they no longer caused inflammation (switching them from M1 to M2 phenotypes).

“We’ve known for a long time that DHA tames inflammation, now, we learn exactly how DHA works: via new substances called maresins,” said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal.

“We encounter inflammation almost daily, but our body has ways of turning it off.

This is an important step toward understanding exactly this happens. You’re likely to be hearing a lot more about maresins if, or when, new therapies arise from this discovery.”

Related Articles:

Omega 3’s-Key thoughts

Omega-3 fats lower-inflammation-slash cancer-heart disease risks

Fish oil-Neurosurgeon for the Pittsburgh Steelers

 

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