Archive for the ‘Chronic Low Back Pain-Medical Hypotheses Journal 2007’ Category

Chronic Low Back Pain-Medical Hypotheses Journal 2007

April 6, 2010

posted by:  Kevin G. Parker, D.C.

Medical Hypotheses JournalVolume 68, Issue 1, January 2007, Pp 74-80

By Helene M. Langevin and Karen J. Sherman (The primary author is from the Department of Neurology, University of Vermont, College of Medicine)

Pathophysiological Model for Chronic Low Back Pain Integrating Connective Tissue and Nervous System Mechanisms


1) In chronic low back pain, there is an integration between connective tissue fibrosis and the nervous system perception of pain.

2) Adverse connective tissue fibrosis can be remodeled by applying mechanical forces to soft tissues, including chiropractic spinal adjusting. (Note, chiropractic was included as the applying of a mechanical force to reverse adverse connective tissue fibrosis and its influence on the nervous system.)

3) The “association between symptoms and imaging results (X-ray, CT, MRI) has been consistently weak, and up to 85 percent of patients with low back pain cannot be given a precise pathoanatomical diagnosis using these methods.”

4) “Ongoing pain is associated with widespread neuroplastic changes at multiple levels within the nervous system and including primary afferent neurons, spinal cord, brainstem, thalamus, limbic system and cortex.”

5) Neuroimaging has shown that there are distinct “brain networks” involved in acute vs. chronic pain. Chronic pain is specifically related to regions for cognition and emotions.

6) Chronic back pain results in neuronal or glial loss in the pre-frontal and thalamic gray matter. (Brain atrophy)

7) “Increased connective tissue stiffness due to fibrosis is an important link in the pathogenic mechanism leading to chronicity of pain.”

8)   “Abnormal movement patterns can have important influences on the connective tissues that surround and infiltrate muscles.” (Joint Dysfunction)

9) “A hallmark of connective tissue is its plasticity or ‘remodeling’ in response to varying levels of mechanical stress.” (This is important because it implies that spinal adjusting/manipulation can initiate remodeling of abnormal connective tissues.)

10) “Both increased stress due to overuse, repetitive movement and/or hypermobility, and decreased stress due to immobilization or hypomobility can cause changes in connective tissue.” (Both increased and decreased motion are deleterious.)

11) A chronic local increase in stress leads to micro-injury and inflammation. (Joint Dysfunction)

12) “A consistent absence of stress leads to connective tissue atrophy, architectural disorganization, fibrosis, adhesions and contractures.”

13) “Fibrosis can be the direct result of hypomobility or the indirect result of hypermobility via injury and inflammation.”

14) During the early phase of immobilization, loss of muscle length is primarily due to shortening of muscle-associated connective tissue, which is later followed by actual shortening of muscle fibers.

15) Muscle connective tissue fibrosis promotes hypomobility. “Connective tissue fibrosis is detrimental, as it leads to increased tissue stiffness and further movement impairment.”

16) “Tissue microinjury, inflammation and fibrosis not only can change the biomechanics of soft tissue (e.g., increased stiffness) but also can profoundly alter the sensory input arising from the affected tissues.” (Very Interesting: Remember many contend that the tissue changes associated with the joint dysfunction can alter the afferent input into the central nervous system)

17) “Connective tissue is richly innervated with mechanosensory and nociceptive neurons.”

18) Activation of nociceptors can contribute to the development or worsening of fibrosis and inflammation, causing even more tissue stiffness and movement impairment.

19) Chronic low back pain may be caused by pathological connective tissue fibrosis, which causes adverse changes in movement. This is well documented in ligaments and joint capsules.  This pathological connective tissue fibrosis is plastic and can, therefore, be remodeled. However, the remodeling must take place over time.

20) “In fibrosed connective tissue and muscle, blood and lymphatic flow may be chronically compromised by the disorganized tissue architecture and, thus, vulnerable to unusual muscle activity (e.g., beginning a new work activity or sport), or to conditions causing further decrease in perfusion such as prolonged sitting.

21) Pain leads to reduced motion, and movement restriction increases fibrosis, “setting the patient up for more painful episodes.”

22)  “In addition to its role in the pathological consequences of immobility and injury, the dynamic and potentially reversible nature of connective tissue plasticity may be key to the beneficial effects of widely used physical therapy techniques as well as ‘alternative’ treatments involving external application of mechanical forces (e.g., massage, chiropractic manipulation, acupuncture), changes in specific movement patterns (e.g., movement therapies, tai chi, yoga) or more general changes in activity levels (e.g., increased recreational exercise).”

23) “Manual or movement-based treatments have the advantage of not causing drug-induced side effects (e.g., gastritis, sedation),” but excessive motion may lead to inflammation.

24) A “carefully applied direct tissue stretch may be necessary in cases of long standing hypomobility with pronounced fibrosis and stiffness.” (Manipulation, mobilization, etc.)

Summary from the article:

Although chronic low back pain (cLBP) is increasingly recognized as a complex syndrome with multifactorial etiology, the pathogenic mechanisms leading to the development of chronic pain in this condition remain poorly understood.

This article presents a new, testable pathophysiological model integrating connective tissue plasticity mechanisms with several well-developed areas of research on cLBP (pain psychology, postural control, neuroplasticity).

We hypothesize that pain-related fear leads to a cycle of decreased movement, connective tissue remodeling, inflammation, nervous system sensitization and further decreased mobility.

In addition to providing a new, testable framework for future mechanistic studies of cLBP, the integration of connective tissue and nervous system plasticity into the model will potentially illuminate the mechanisms of a variety of treatments that may reverse these abnormalities by applying mechanical forces to soft tissues (e.g. physical therapy, massage, chiropractic manipulation, acupuncture), by changing specific movement patterns (e.g. movement therapies, yoga) or more generally by increasing activity levels (e.g. recreational exercise).

Non-invasive measures of connective tissue remodeling may eventually become important tools to evaluate and follow patients with cLBP in research and clinical practice. An integrative mechanistic model incorporating behavioral and structural aspects of cLBP will strengthen the rationale for a multidisciplinary treatment approach including direct mechanical tissue stimulation, movement reeducation, psychosocial intervention and pharmacological treatment to address this common and debilitating condition.

Related articles:

Chronic Spine pain-Journal of Spine 2003-JMPT 2005

Article on Acute Low Back Pain- Chiropractic vs M.D.

Fascia-The Secret Life of Fascia-Charles Poliquin blog 2011

Fascia-The Web of Life

Fascia and stretching-The Fuzz Speech-Gil Hedley, Ph.D.

Chiropractic Manipulation and Rehabilitation Irvine Calif. 

Manipulation in Improving Motion and Joint Health ~Review of Medical literature

Healing Time of Soft Tissue

Back Pain and Your Brain

Pain Persisting after stressful events may have a Neurobiological Basis-N.C.School of Med

 Back Pain-2013 MRI study reveals how chiropractic helps spine joint mobility

Why Does Back Pain Recur?

The Science of Spine and Joint Health

Chiropractic Listed as Lower Back Treatment Option in Medical Jr. JAMA-2013

Chiropractic vs. Medicine for Acute Low Back Pain- Spine Journal 2010:

Chiropractic cost effective-Blue Cross Blue Shield claims analysis-JMPT 2010:

Chiropractic Care Cost effective

Spine Manipulation compared to NSAIDS-Spine J Vol 38, No 7 2013

Sciatica-like symptoms derived from the Sacroiliac Joint-Eur Spine J. 2013

Cervical spine manipulation-Clinical Neurophysiology 2007

Chiropractic care-reduce disability recurrences-Jr of Occupational and Enviro Med-2011

Chiropractic may reduce elderly injuries-2012

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