Archive for the ‘Vit D dosing during pregnancy improved maternal-neonatal outcome- Am J Obstet Gynecol. 2012’ Category

Vit D dosing during pregnancy improved maternal-neonatal outcome- Am J Obstet Gynecol. 2012

December 14, 2012

Posted by:   Kevin G. Parker, D.C.

Pub Med.Gov:  Am J Obstet Gynecol. 2012 Nov 3
Am J Obstet Gynecol. 2012 Nov 3. pii: S0002-9378(12)02035-2. doi: 10.1016/j.ajog.2012.10.888. [Epub ahead of print]

Key points:

1.  Largest randomized controlled trial to date using meaningful daily doses (2,000 vs. 4,000 IU) of vitamin D during pregnancy.

2.  The ethics committee would not let them use a control group of 400 IU/day, as the committee felt this would endanger the women and their newborns. Sadly, most women in this country only take the 400 IU/day in their prenatal vitamin.
A randomized trial of vitamin D supplementation in 2 community health center networks in South Carolina.
Wagner CL, McNeil R, Hamilton SA, Winkler J, Rodriguez Cook C, Warner G, Bivens B, Davis DJ, Smith PG, Murphy M, Shary JR, Hollis BW.
Source:  Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, Charleston. Electronic address:

Maternal supplementation with vitamin D 2000 and 4000 IU/d during pregnancy improved maternal/neonatal vitamin D status.

Evidence of risk reduction in infection, preterm labor, and preterm birth was suggestive, requiring additional studies powered for these endpoints.
We sought to determine whether 4000 IU/d (vs 2000 IU/d) of vitamin D during pregnancy is safe and improves maternal/neonatal 25-hydroxyvitamin D [25(OH)D] in a dose-dependent manner.
A total of 257 pregnant women 12-16 weeks’ gestation were enrolled. Randomization to 2000 vs 4000 IU/d followed 1-month run-in at 2000 IU/d. Participants were monitored for hypercalciuria, hypercalcemia, and 25(OH)D status.
Maternal 25(OH)D (n = 161) increased from 22.7 ng/mL (SD 9.7) at baseline to 36.2 ng/mL (SD 15) and 37.9 ng/mL (SD 13.5) in the 2000 and 4000 IU groups, respectively. While maternal 25(OH)D change from baseline did not differ between groups, 25(OH)D monthly increase differed between groups (P < .01). No supplementation-related adverse events occurred. Mean cord blood 25(OH)D was 22.1 ± 10.3 ng/mL in 2000 IU and 27.0 ± 13.3 ng/mL in 4000 IU groups (P = .024). After controlling for race and study site, preterm birth and labor were inversely associated with predelivery and mean 25(OH)D, but not baseline 25(OH)D.

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